Recombination Hotspot Activity in Drosophila Melanogaster
ثبت نشده
چکیده
MELANOGASTER By MAHROSE MEHDI A thesis submitted to the Graduate School-New Brunswick Rutgers, The State University of New Jersey and The Graduate School of Biomedical Sciences University of Medicine and Dentistry of New Jersey in partial fulfillment of the requirements for the degree of Master of Science Graduate Program in Cell and Developmental Biology written under the direction of Dr. Kim McKim and approved by ________________________ ________________________ ________________________
منابع مشابه
Statistical inference of recombination-inducing genic features in Drosophila melanogaster
Building on the findings of Chan et al. [1], this work applies a variety of computational methods to further our limited understanding of recombination-initiating processes in Drosophila melanogaster. Using recently produced high resolution recombination maps for two different D. melanogaster populations, we identify recombination hotspots (regions of extremely elevated recombination activity) ...
متن کاملAconitase and Developmental EndPointsasEarly IndicatorsofCellularToxicity Induced by Xenobiotics in Drosophila Melanogaster
Background: In this study, the toxicity of the different xenobiotics was tested on the fruit fly Drosophila melanogaster model system. Methods: Fly larvae were raised on food supplemented with xenobioticsat different concentrations (sodium nitroprusside (0.1-1.5 mM), S-nitrosoglutathione (0.5-4 mM), and potassium ferrocyanide (1 mM)). Emergence of flies, food intake by larvae, and pupation h...
متن کاملA recombinational hotspot at the triplo-lethal locus of Drosophila melanogaster.
In the genome of Drosophila melanogaster there is only one locus, Tpl, that is triplo-lethal; it is also haplo-lethal. Previous work has identified 3 hypomorphic alleles of Tpl which rescue animals carrying a duplication of Tpl, but which are not dominant lethals as null mutations or deficiencies would be. We have found that all three hypomorphic alleles act as site-specific hotspots for recomb...
متن کاملReciprocal recombination and the evolution of the ribosomal gene family of Drosophila melanogaster.
The role of reciprocal recombination in the coevolution of the ribosomal RNA gene family on the X and Y chromosomes of Drosophila melanogaster was assessed by determining the frequency and nature of such exchange. In order to detect exchange events within the ribosomal RNA gene family, both flanking markers and restriction fragment length polymorphisms within the tandemly repeated gene family w...
متن کاملConcentration dependent effect of morphine, aspirin, capsaicin and chili pepper hydro alcoholic extract on thermal and chemical pain model in fruit fly (Drosophila melanogaster)
Introduction: Pain research using animal models is related to ethical concerns, so invertebrates and insects have been recommended by researchers. In the present study, the nociceptive and antinociceptive effects of capsaicin, aspirin, morphine and chili extract were examined using fruit fly (Drosophila melanogaster) as an alternative for rodent pain model. Methods: Stage 3 of larvae and ad...
متن کامل